Intravitreal injection worsens outcomes in a mouse model of indirect traumatic optic neuropathy from closed globe injury
نویسندگان
چکیده
منابع مشابه
Indirect traumatic optic neuropathy
Indirect traumatic optic neuropathy (ITON) refers to optic nerve injury resulting from impact remote to the optic nerve. The mechanism of injury is not understood, and there are no confirmed protocols for prevention, mitigation or treatment. Most data concerning this condition comes from case series of civilian patients suffering blunt injury, such as from sports- or motor vehicle-related concu...
متن کاملIndirect traumatic optic neuropathy--two case report.
The aim of the study was to evaluate the treatment of indirect traumatic optic neuropathy (ITON). ITON is defined as traumatic loss of vision that occurs without external or initial ophthalmoscopic evidence of injury to the eye or its nerve. The optimal management of ITON remains controversial. History, clinical findings and treatment of two cases of ITON with high-dose corticosteroids are desc...
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متن کاملIntravitreal Transplantation of Human Umbilical Cord Blood Stem Cells Protects Rats from Traumatic Optic Neuropathy
OBJECTIVES To treat traumatic optic neuropathy (TON) with transplantation of human umbilical cord blood stem cells (hUCBSC) and explore how transplanted stem cells participate in the neuron repairing process. METHODS A total of 195 Sprague-Dawley rats were randomly assigned to three groups: sham-surgery, optic nerve injury, and stem cell transplant group. Optic nerve injury was established in...
متن کاملTraumatic ischaemic optic neuropathy.
Persistent profound visual loss following contusion of the globe or ocular adnexae has been well documented, the visual loss being attributed to haemorrhage into, or contusion of, the optic nerve, or to interference with the blood supply of the eye. The patient described below presented after a contusion of the eye and orbit, with the clinical picture of ischaemic optic neuropathy presumably re...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2021
ISSN: 0014-4835
DOI: 10.1016/j.exer.2020.108369